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Five patients with oropharyngeal cancer treated with 5-fluorouracil and cisplatin had ischemic stroke within 2 to 5 days after the drug infusion. This occurred during the second course of chemotherapy in three patients, and during the third course in two patients.There may be a relation between treatment and brain infarction because 1)there was no other cause identified despite extensive tests,including postmortem examination in one patient;2)there was a short delay between treatment infusion and stroke; and 3)there was a similar pattern of ischemic stroke after the second or third course of chemotherapy. |
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